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擅長領(lǐng)域：1. 吸入麻醉藥肝毒性機理及防治研究 2. 圍術(shù)期肝保護的綜合策略 3. 肝移植麻醉與圍術(shù)期處理 4. 肝切除病人麻醉(大出血、凝血、液體治療、術(shù)后鎮(zhèn)痛等) 5. 黃疸麻醉的基礎(chǔ)臨床研究?

執(zhí)業(yè)經(jīng)歷： 職 稱：主任醫(yī)師 　　職 務(wù)：科主任 　　院 區(qū)：東院 　　科 室：麻醉科 　　醫(yī)療專長：1. 吸入麻醉藥肝毒性機理及防治研究 2. 圍術(shù)期肝保護的綜合策略 3. 肝移植麻醉與圍術(shù)期處理 4. 肝切除病人麻醉(大出血、凝血、液體治療、術(shù)后鎮(zhèn)痛等) 5. 黃疸麻醉的基礎(chǔ)臨床研究 　　教育經(jīng)歷 　　1980-1985 第二軍醫(yī)大學(xué)軍醫(yī)本科 　　1985-1989 長海醫(yī)院麻醉科住院醫(yī)師 　　1989-1992 第二軍醫(yī)大學(xué)麻醉學(xué)碩士(導(dǎo)師王景陽教授) 　　1992-1994 第二軍醫(yī)大學(xué)外科學(xué)博士(導(dǎo)師吳孟超院士) 　　1994-1997 東方肝膽外科醫(yī)院麻醉科副主任，主治醫(yī)師講師 　　1997-2002 東方肝膽外科醫(yī)院麻醉科主任，副主任醫(yī)師副教授，碩導(dǎo) 　　2002- 東方肝膽外科醫(yī)院麻醉科主任，主任醫(yī)師 　　學(xué)術(shù)職務(wù) 　　1. 世界麻醉醫(yī)師協(xié)會聯(lián)盟疼痛學(xué)會委員(中國在該聯(lián)盟中5位委員之一) 　　2. 中國醫(yī)師協(xié)會麻醉學(xué)醫(yī)師分會會長 　　3. 中華醫(yī)學(xué)會麻醉學(xué)分會常委兼秘書長 　　4. 上海市醫(yī)學(xué)會麻醉?？莆瘑T會主任委員 　　5. 全軍麻醉與復(fù)蘇專業(yè)委員會常委 　　6. 國內(nèi)四本主要的麻醉學(xué)雜志的編委、常務(wù)編委或副總編等 　　7. 國家自然基金二審專家(神經(jīng)精神組) 　　論文著作 　　SCI 　　1. Yang LQ, Li SJ, Cao YF, Man XB, Yu WF, Wang HY, Wu MC. Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases. World J Gastroenterol. 2003 Feb;9(2):359-63. (IF: 2.547). (Citation: 24, Self-citation: 1) 　　2. Yang LQ, Yu WF, Cao YF, Gong B, Chang Q, Yang GS. Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes. World J Gastroenterol. 2003 Sep;9(9):1959-62. (IF: 2.547). (Citation: 11, Self-citation: 0) 　　3. Li Q, Yu WF, Zhou MT, Lu X, Yang LQ, Zhu M, Song JG, Lu JH. Isoflurane preserves energy balance in isolated hepatocytes during in vitro anoxia/reoxygenation. World J Gastroenterol. 2005 Jul 7;11(25):3920-4. (IF: 2.547). (Citation: 4, Self-citation: 0) 　　4. Yu WF, Yang LQ, Zhou MT, Liu ZQ, Li Q. Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats. World J Gastroenterol. 2005 Aug 28;11(32):5025-8. (IF: 2.547). (Citation: 7, Self-citation: 0) 　　5. Song JG, Cao YF, Yang LQ, Yu WF, Li Q, Song JC, Fu XY, Fu Q. Awakening concentration of desflurane is decreased in patients with obstructive jaundice. Anesthesiology. 2005 Mar;102(3):562-5. (IF: 5.486). (Citation: 7, Self-citation: 3) 　　6. Song JC, Sun YM, Zhang MZ, Yang LQ, Song JG, Wang ZM, Yu WF. Propofol pharmacokinetics in patients with obstructive jaundice. Curr Drug Deliv. 2009 Jul;6(3):317-20. (IF: 2.288). (Citation: 3, Self-citation: 1) 　　7. Song JC, Zhang MZ, Lu ZJ, Yang LQ, Song JG, Sun YM, Yu WF. The effects of obstructive jaundice on the pharmacodynamics of propofol: does the sensitivity of intravenous anesthetics change among icteric patients? Acta Anaesthesiol Scand. 2009 Nov;53(10):1329-35. (IF: 2.196). (Citation: 5, Self-citation: 2) 　　8. Song JG, Cao YF, Sun YM, Ge YH, Xu XW, Yang LQ, Liu ZQ, Song SL, Yu WF. Baroreflex sensitivity is impaired in patients with obstructive jaundice. Anesthesiology. 2009 Sep;111(3):561-5. (IF: 5.486). (Citation: 4, Self-citation: 2) 　　9. Xu XW, Pei SJ, Miao XR, Yu WF. Human signal peptide had advantage over mouse in secretory expression. Histochem Cell Biol. 2009 Aug;132(2):239-46. (IF: 2.613). (Citation: 2, Self-citation: 1) 　　10. Li Z, Shi J, Liao Z, Wu FX, Yang LQ, Yu WF. Scientific publications in anesthesiology journals from mainland China, Taiwan, and Hong Kong: a 10-year survey of the literature. Anesth Analg. 2010 Mar 1;110(3):918-21. (IF: 3.3). (Citation: 6, Self-citation: 2) 　　11. Song JC, Sun YM, Yang LQ, Zhang MZ, Lu ZJ, Yu WF. A comparison of liver function after hepatectomy with inflow occlusion between sevoflurane and propofol anesthesia. Anesth Analg. 2010 Oct;111(4):1036-41. (IF: 3.3). (Citation: 7, Self-citation: 2) 　　12. Yang LQ, Song JC, Irwin MG, Song JG, Sun YM, Yu WF. A clinical prospective comparison of anesthetics sensitivity and hemodynamic effect among patients with or without obstructive jaundice. Acta Anaesthesiol Scand. 2010 Aug;54(7):871-7. (IF: 2.196). (Citation: 3, Self-citation:1) 　　13. Miao XR, Gao XF, Wu JX, Lu ZJ, Huang ZX, Li XQ, He C, Yu WF. Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells. BMC Cancer. 2010 May 20;10:216. (IF: 3.333). (Citation: 12, Self-citation: 1) 　　14. Wu FX, Bian JJ, Miao XR, Huang SD, Xu XW, Gong DJ, Sun YM, Lu ZJ, Yu WF. Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain. Int J Med Sci. 2010 Aug 2;7(5):251-9. (IF: 2.065). (Citation: 18, Self-citation: 3) 　　15. Yang LQ, Tao KM, Cheung CW, Liu YT, Tao Y, Wu FX, Yu WF. The effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patients. Anaesthesia. 2010 Nov 65(11):1094-1100. (IF: 3.008). (Citation: 1, Self-citation: 0) 　　16. Li Z, Liao Z, Wu FX, Yang LQ, Sun YM, Yu WF. Scientific publications in critical care medicine journals from Chinese authors: a 10-year survey of the literature. J Trauma. 2010 Oct;69(4):E20-3. (IF: 2.348). (Citation: 7, Self-citation: 1) 　　17. Tao KM, Yang LQ, Liu YT, Tao Y, Song JC, Wu FX, Yu WF. Volatile anesthetics might be more beneficial than propofol for postoperative liver function in cirrhotic patients receiving hepatectomy. Med Hypotheses. 2010 Dec;75(6):555-7. (IF: 1.054). (Citation: 2, Self-citation: 0) 　　18. Lu ZJ, Miao XR, Wu JX, Wang XY, Miao Q, Yu WF. Acute PAR2 activation reduces alpha, beta-MeATP sensitive currents in rat dorsal root ganglion neurons. Neuroreport. 2010 Feb 17;21(3):227-32. (IF: 1.404). (Citation: 4, Self-citation: 1) 　　19. Yang T, Zhang J, Lu JH, Yang LQ, Yang GS, Wu MC, Yu WF. A new staging system for resectable hepatocellular carcinoma: comparison with six existing staging systems in a large Chinese cohort. J Cancer Res Clin Oncol. 2011 May;137(5):739-50. (IF: 2.914). (Citation: 13, Self-citation: 7) 　　20. Li Z, Qiu LX, Wu FX, Yang LQ, Sun YM, Yu WF. Scientific publications in anesthesiology journals from East Asia: a 10-year survey of the literature. J Anesth. 2011 Apr;25(2):257-62. (IF: 0.867). (Citation: 3, Self-citation: 3) 　　21. Song JC, Sun YM, Zhang MZ, Yang LQ, Tao TZ, Yu WF. The etomidate requirement is decreased in patients with obstructive jaundice. Anesth Analg. 2011 Nov;113(5):1028-32. (IF: 3.3). (Citation: 1, Self-citation: 1) 　　22. Li Z, Qiu LX, Wu FX, Yang LQ, Sun S, Yu WF. Scientific publications in international anaesthesiology journals: a 10-year survey. Anaesth Intensive Care. 2011 Mar;39(2):268-73. (IF: 1.396). (Citation: 3, Self-citation: 1) 　　23. Yang LQ, Tao KM, Liu YT, Cheung CW, Irwin MG, Wong GT, Lv H, Song JG, Wu FX, Yu WF. Remifentanil preconditioning reduces hepatic ischemia-reperfusion injury in rats via inducible nitric oxide synthase expression. Anesthesiology. 2011 May;114(5):1036-47. (IF: 5.486). (Citation: 16, Self-citation: 0) 　　24. Lv X, Yang L, Tao K, Liu Y, Yang T, Chen G, Yu W, Lv H, Wu F. Isoflurane preconditioning at clinically relevant doses induce protective effects of heme oxygenase-1 on hepatic ischemia reperfusion in rats. BMC Gastroenterol. 2011 Mar 31;11:31. (IF: 2.11). (Citation: 8, Self-citation: 0) 　　25. Ren HM, Yang LQ, Liu ZQ, Chen CY, Cheung CW, Tao KM, Song JG, Chen WR, Yu WF. In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice. BMC Gastroenterol. 2011 Dec 28;11:144. (IF: 2.11). (Citation: 0, Self-citation: 0) 　　26. He Y, Wu FX, Miao XR, Xu XW, Sun YM, Chen CY, Yu WF. Suppression of acute morphine withdrawal syndrome by adenovirus-mediated β-endorphin in rats. Brain Res. 2011 Nov 8;1422:13-9. (IF: 2.879). (Citation: 1, Self-citation: 0) 　　27. Huang Z, Tao K, Zhu H, Miao X, Wang Z, Yu W, Lu Z. Acute PAR2 activation reduces GABAergic inhibition in the spinal dorsal horn. Brain Res. 2011 Nov 24;1425:20-6. (IF: 2.879). (Citation: 1, Self-citation: 0) 　　28. Wang Z, Sun Y, Wang Z, Wang Q, Yu W. Anesthetic management of injuries following the 2008 Wenchuan, China earthquake. Eur J Trauma Emerg Surg (2011) 37:9–12. (IF: 0.263). (Citation: 0, Self-citation: 0) 　　29. Lv X, Wang ZM, Huang SD, Song SH, Wu FX, Yu WF. Emulsified isoflurane preconditioning reduces lung injury induced by hepatic ischemia/reperfusion in rats. Int J Med Sci. 2011;8(5):353-61. (IF: 2.065). (Citation: 6, Self-citation: 1) 　　30. Wang Z, Bao Y, Lu Z, Yu W. Is neuromuscular relaxation of rocuronium prolonged in patients with obstructive jaundice? Med Hypotheses. 2011 Jan;76(1):100-1. (IF: 1.054). (Citation: 1, Self-citation: 1) 　　31. Tao KM, Li XQ, Zhou QH, Moher D, Ling CQ, Yu WF. From QUOROM to PRISMA: a survey of high-impact medical journals' instructions to authors and a review of systematic reviews in anesthesia literature. PLoS One. 2011;6(11):e27611. (IF: 3.73). (Citation: 2, Self-citation: 0) 　　32. Yang T, Zhang J, Lu JH, Yang GS, Wu MC, Yu WF. Risk factors influencing postoperative outcomes of major hepatic resection of hepatocellular carcinoma for patients with underlying liver diseases. World J Surg. 2011 Sep;35(9):2073-82. (IF: 2.228). (Citation: 15, Self-citation: 0) 　　33. Wu JX, Xu MY, Miao XR, Lu ZJ, Yuan XM, Li XQ, Yu WF. Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain. Eur J Pain. 2012 Nov;16(10):1378-88. (IF: 3.067). (Citation: 7, Self-citation: 0) 　　34. Wu F, Xu X, Miao X, Chen J, Sun Y, Yu W. Effect of recombinant adenovirus coding for endomorphin-2 on neuropathic pain in rats. Int J Clin Exp Pathol. 2012;5(9):914-23. (IF: 2.242). (Citation: 1, Self-citation: 0) 　　35. Wu F, Miao X, Chen J, Sun Y, Liu Z, Tao Y, Yu W. Down-regulation of GAP-43 by inhibition of caspases-3 in a rat model of neuropathic pain. Int J Clin Exp Pathol. 2012;5(9):948-55. (IF: 2.242). (Citation: 2, Self-citation: 0) 　　36. Li Z, Wu FX, Yang LQ, Sun YM, Lu ZJ, Yu WF. Citation classics in main pain research journals. J Anesth. 2012 Feb;26(1):85-93. (IF: 0.867). (Citation: 5, Self-citation: 0) 　　37. Wu F, Liu Y, Lv X, Miao X, Sun Y, Yu W. Small interference RNA targeting TLR4 gene effectively attenuates pulmonary inflammation in a rat model. J Biomed Biotechnol. 2012;2012:406435. (IF: 2.88). (Citation: 3, Self-citation: 0) 　　38. Li Z, Qiu LX, Wu FX, Yang LQ, Sun YM, Lu ZJ, Yu WF. Assessing the national productivity in subspecialty critical care medicine journals: a bibliometric analysis. J Crit Care. 2012 Dec;27(6):747.e1-5. (IF: 2.489). (Citation: 0, Self-citation: 0) 　　39. Song JC, Zhang MZ, Wu QC, Lu ZJ, Sun YM, Yang LQ, Yu WF. Sevoflurane has no adverse effects on renal function in cirrhotic patients: a comparison with propofol. Acta Anaesthesiol Scand. 2013 Aug;57(7):896-902. (IF: 2.196). (Citation: 0, Self-citation: 0) 　　40. Wu F, Miao X, Chen J, Liu Z, Tao Y, Yu W, Sun Y. Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain. Int J Clin Exp Pathol. 2013 Jul 15;6(8):1516-22. (IF: 2.242). (Citation: 0, Self-citation: 0) 　　41. Wang Z, Lv H, Song S, Shen X, Yang L, Yu W. Emulsified isoflurane preconditioning protects isolated rat Kupffer cells against hypoxia/reoxygenation-induced injury. Int J Med Sci. 2013;10(3):286-91. (IF: 2.065). (Citation: 0, Self-citation: 0) 　　42. Lu YG, Wei W, Wang L, Tao KM, Sun YM, You ZD, Yu WF. Ultrasound-guided cerebrospinal fluid collection from rats. J Neurosci Methods. 2013 May 15;215(2):218-23. (IF: 2.114). (Citation: 0, Self-citation: 0) 　　43. Wang ZM, Zhang P, Lin MJ, Tan B, Qiu HB, Yu WF. Influence of obstructive jaundice on pharmacodynamics of rocuronium. PLoS One. 2013 Oct 16;8(10):e78052. (IF: 3.73). (Citation: 0, Self-citation: 0) 　　44. Li Z, Sun YM, Wu FX, Yang LQ, Lu ZJ, Yu WF. Equal contributions and credit: an emerging trend in the characterization of authorship in major anaesthesia journals during a 10-yr period. PLoS One. 2013 Aug 5;8(8):e71430. (IF: 3.73). (Citation: 0, Self-citation: 0) 　　45. Chen Q, Chen P, Zhou S, Yan X, Zhang J, Sun X, Yuan H, Yu W. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci. 2013 Nov;40(6):857-63. (IF: 1.332). (Citation: 0, Self-citation: 0) 　　46. Ge Y, Wu F, Sun X, Xiang Z, Yang L, Huang S, Lu Z, Sun Y, Yu WF. Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats. PLoS One. 2014 May 23;9(5):e97436. PLoS One. 2014 May 23;9(5):e97436. (IF: 3.73). (Citation: 0, Self-citation: 0) 　　47. Li Z, Sun YM, Wu FX, Yang LQ, Lu ZJ, Yu WF. Controlled low central venous pressure reduces blood loss and transfusion requirements in hepatectomy. World J Gastroenterol. 2014 Jan 7;20(1):303-9. (IF: 2.547). (Citation: 0, Self-citation: 0) 　　48. Tao KM, Tao Y, Chen CY, Yang LQ, Lu ZJ, Sun YM, Huang SD, Yu WF. Proteinase-activated Receptor 1 Contributed to Up-regulation of Enkephalin in Keratinocytes of Patients with Obstructive Jaundice. Anesthesiology. 2014 Mar 7. (IF: 6.186). (Citation: 0, Self-citation: 0) 　　49. Huang ZX, Lu ZJ, Ma WQ, Wu FX, Zhang YQ, Yu WF, Zhao ZQ. Involvement of RVM-expressed P2X7 receptor in bone cancer pain: mechanism of descending facilitation. Pain. 2014 Apr;155(4):783-91. (IF: 5.844). (Citation: 0, Self-citation: 0) 　　50. Zhang C, Wang Z, Zhang J, Qiu H, Sun Y, Yang L, Wu F, Zheng J, Yu W. Competitive inhibition of the nondepolarizing muscle relaxant rocuronium on nicotinic acetylcholine receptor channels in the rat superior cervical Ganglia. J Cardiovasc Pharmacol. 2014 May;63(5):428-33. (IF: 2.383). (Citation: 0, Self-citation: 0) 　　51. Liu Y, Yang L, Tao K, Vizcaychipi MP, Lloyd DM, Sun X, Irwin MG, Ma D, Yu W. Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol. 2014 Jan 12;14:12. (IF: 2.11). (Citation: 0, Self-citation: 0) 　　52. Kun-Ming Tao, Xiao-Qian Li, Li-Qun Yang, Wei-Feng Yu, Zhi-Jie Lu, Yu-Ming Sun, Fei-Xiang Wu. Glutamine supplementation for critically ill adults. Cochrane Database Syst Rev. Published Online: 12 SEP 2012. (IF: 5.703). (Citation: 0, Self-citation: 0) 　　主編著作： 　　1. 曹云飛,俞衛(wèi)鋒,王士雷主編.全麻原理及研究新進展.人民軍醫(yī)出版社2005年 (67萬字) 　　2. 杭燕南，俞衛(wèi)鋒，王祥瑞主編。吸入麻醉藥 世界圖書出版公司2008年3月(53萬字) 　　3. 俞衛(wèi)鋒主編 麻醉與復(fù)蘇新論 第二軍醫(yī)大學(xué)出版社 2001年6月(120萬字) 　　4. 李保春 俞衛(wèi)鋒 袁偉杰主編 人民軍醫(yī)出版社 2004年2月(83萬字) 　　5. 陸智杰 俞衛(wèi)鋒主編 人民軍醫(yī)出版社 2013年2月(55萬字) 　　課題研究 　　1、鹵代類吸入麻醉藥的肝毒性研究，國家自然科學(xué)基金(39170713)，1991-1994 　　2、吸入麻醉藥肝毒性與肝線粒體功能及膜分子機制的研究，國家自然科學(xué)基金(39400126)，1994-1997 　　3、阻塞性黃疸導(dǎo)致吸入全麻藥敏感性增高的突觸傳遞機制研究，國家自然科學(xué)基金(81072625)，2011-2013 　　4、活性氧作用于α腎上腺受體致阻塞性黃疸血管低反應(yīng)性，國家自然科學(xué)基金(81170427)，2012-2015 　　5、miR-150調(diào)控內(nèi)皮祖細胞修復(fù)血管內(nèi)皮介導(dǎo)阻黃血管低反應(yīng)，國家自然科學(xué)基金(81370513)，2014-2017 　　6、肝移植中異丙酚藥代動力學(xué)研究，軍隊醫(yī)藥基金項目(98Q50)，1998-2001 　　7、上海市臨床醫(yī)學(xué)中心，上海市專項基金(ZX01B05)，2001-2002 　　8、肝臟手術(shù)圍術(shù)期肝功能保護策略研究，上海市科委生物醫(yī)藥重點項目(10411952000)，2011-2013 　　9、阻塞性黃疸導(dǎo)致吸入全麻藥敏感性增高的突觸傳遞機制研究，上海市教育委員會科研創(chuàng)新項目/重點項目，2011-2013 　　10、阻塞性黃疸導(dǎo)致吸入全麻藥敏感性增高的突觸傳遞機制研究，上海市科委優(yōu)秀學(xué)科帶頭人計劃(11XD1406800)，2012-2015 　　創(chuàng)新專利 　　1.俞衛(wèi)鋒,徐學(xué)武.一種獲得內(nèi)嗎啡肽的方法及其在疼痛治療中的應(yīng)用(200510118974.0) 　　2.俞衛(wèi)鋒,徐學(xué)武.可基因整合的重組腺相關(guān)病毒載體的構(gòu)建方法.(200510118975.5) 　　3.俞衛(wèi)鋒，吳飛翔 一種用于戒毒的生物新方法 (香港國際發(fā)明博覽會金獎) 　　4. 俞衛(wèi)鋒，吳飛翔 一種人鼠同源性NMDA受體NR2B的小RNA及其應(yīng)用(907676) 　　獲得榮譽 　　1. 吸入麻醉藥的研究 2004年國家科技進步二等獎 (第二) 　　2. 吸入麻醉藥肝毒性機制的研究 2002 年軍隊科技進步二等獎 (第一) 　　3. 肝膽疾患圍術(shù)期血液內(nèi)環(huán)境紊亂機制 2006年軍隊科技進步三等獎(第二) 　　4. 2007年軍隊院校育才獎 銀獎 　　5. 2006年上海市衛(wèi)生系統(tǒng)“銀蛇獎” 銀獎 　　6. 2005年上海市優(yōu)秀醫(yī)學(xué)青年人才計劃 (固定帶教老師) 　　7. 2006年上海市科技啟明星 (指導(dǎo)老師) 　　8. 2008年上海市科技啟明星 (指導(dǎo)老師) 　　9. 2011年上海市優(yōu)秀學(xué)科帶頭人 　　10. 2011年軍隊二類津貼 　　11. 2011 年上海市優(yōu)秀博士論文 (導(dǎo)師 俞衛(wèi)鋒 ) 　　12. 2013年上海市科技精英提名獎 詳細介紹